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Use of lipid-lowering drugs by patients receiving highly active antiretroviral therapy

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  • Medicine


311 An Estimate of the Proportion of Symptoms Reported in Self-Administered Questionnaires That Are Captured as Adverse Drug Events in an Observational Database Janet Raboud,1,2 Maia Lesosky,3 Sherine Sterling,1 Elizabeth Phillips,4 Sharon Walmsley,1,2 and Ahmed Bayoumi2,5,6 1Department of Medicine, University Health Network, University of Toronto, Ontario, Canada; 2Faculty of Medicine, University of Toronto, Ontario, Canada; 3Prosserman Center for Health Research, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada; 4Centre for Pharmacology & Infectious Diseases, Murdoch University, Royal Perth Hospital, Perth, Western Australia; 5Centre for Research on Inner City Health, The Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Toronto, Ontario, Canada; 6Department of Health Policy, Management, and Evaluation, University of Toronto, Ontario, Canada Purpose: This study was conducted to determine how frequently self-reported symptoms are captured as adverse drug events (ADEs) during chart abstraction. Method: We studied Ontario Cohort Study (OCS) participants attending the Toronto Hospital Immunodeficiency Clinic and compared OCS data on ADEs collected semi- annually through chart review and a self-administered questionnaire, completed on up to three occasions, which asked about the frequency, severity, and chronicity of symptoms including diarrhea, nausea, fatigue, and changes in body shape. Among 64 participants who completed the questionnaires, the median age was 42 years, the median time since HIV diagnosis was 9 years, 84% were male, 58% were men who had sex with men, 70% had viral load levels below 50 copies/mL, and the me- dian CD4 was 422 cells/mm3. All patients were taking antiretroviral therapy. Results: The median (interquartile range) number of symptoms per participant reported on the questionnaire at the first visit was 3 (1–5). The most common symptoms reported by patients were diarrhea (58%), headache

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