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Studies on the formation and stability of isoindoles derived from amino acids,o-phthalaldehyde andN-acetyl-l-cysteine

Authors
Journal
Analytical Biochemistry
0003-2697
Publisher
Elsevier
Publication Date
Volume
180
Issue
1
Identifiers
DOI: 10.1016/0003-2697(89)90107-3

Abstract

Abstract A kinetic-spectrophotometric study is performed on the formation and degradation of the isoindole derivatives of amino acids with o-phthalaldehyde and N-ace-tyl- l-cysteine. The experimental and structural factors which affect the formation and stability of the compounds are considered, and the results are compared with those obtained for mercaptoethanol. N-Acetyl- l-cysteine derivatives are highly stable, not requiring a strict control of the time of reaction as in the case of mercaptoethanol.

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