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Human forkhead L2 represses key genes in granulosa cell differentiation including aromatase, P450scc, and cyclin D2

Authors
Journal
Fertility and Sterility
0015-0282
Publisher
Elsevier
Publication Date
Volume
94
Issue
1
Identifiers
DOI: 10.1016/j.fertnstert.2009.09.050

Abstract

FOXL2 is expressed in granulosa cells (GC) of small and medium ovarian follicles, functions as a repressor of the human steroidogenic acute regulatory gene, a marker of a GC differentiation, and its mutation is associated with premature ovarian failure (POF) in women with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES), type I. We now report that FOXL2 also represses the transcription of aromatase, P450scc, and cyclin D2, three other key genes involved in GC proliferation, differentiation, and steroidogenesis, and that a FOXL2 mutation found in patients with BPES type I, also fails to repress aromatase transcription, further supporting a role for FOXL2 in follicle maturation.

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