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Molecular Interactions of Hormonal Steroids: The participation of the 17β side chain of corticosteroids in the formation of complexes with Co (II). Part II.

Authors
Journal
Steroids
0039-128X
Publisher
Elsevier
Publication Date
Volume
20
Issue
4
Identifiers
DOI: 10.1016/0039-128x(72)90037-2

Abstract

Abstract The c 20-c 21 α-ketol system of the 176 side chain of deoxycorti-costerone is in equilibrium with its c 20-c 21 enediol. The apparent dissociation constant of this enol was determined by a photometric method using crystal violet indicator; p K a 1 = 10.65 ± 044. Formation constants of the (1:1) deoxycorticosterone-cobalt (II) complex were determined by solvent extraction and in mixed solvent systems. The complex formation constant K f in an aqueous medium was found by graphical extrapolation to be 2.5–3.0 × 10 −1 1. mole −1

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