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Reciprocal effect of optical isomerism of EW-dipeptides on immune response

Authors
Journal
Immunology Letters
0165-2478
Publisher
Elsevier
Publication Date
Volume
67
Issue
1
Identifiers
DOI: 10.1016/s0165-2478(98)00149-7
Keywords
  • Enantiomeric Peptides
  • D-Amino Acids
  • Immunosuppression
  • Cfu-Stimulation/Suppression
  • Bone Marrow Cells

Abstract

Abstract Dipeptides of the EW-sequence, consisting of d-amino acids, were shown to inhibit spleen colony formation both after in vitro treatment of bone marrow and after the peptide injection to the donor 2–48 h prior to bone marrow taking. The inhibiting effect of d-(EW) peptides can be eliminated by injection of thymic cells to the recipient. l-(EW) peptides have no influence on colony forming activity of intact bone marrow cells but stimulate regeneration of colony formation by irradiated (1 Gy) bone marrow. Unlike l-(EW), the d-(EW) peptides suppress the development of hemopoietic stem cells into the S-phase. Supposedly, d-(EW) represent a new generation of immunoactive peptides possessing of inhibiting activity.

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