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Chronic active VZV infection manifesting as zoster sine herpete, zoster paresis and myelopathy

Authors
Journal
Journal of the Neurological Sciences
0022-510X
Publisher
Elsevier
Publication Date
Volume
212
Identifiers
DOI: 10.1016/s0022-510x(03)00081-9
Keywords
  • Zoster Sine Herpete
  • Zoster Paresis
  • Zoster Myelopathy
Disciplines
  • Medicine

Abstract

Abstract After lumbar-distribution zoster, an HTLV-1-seropositive woman developed chronic radicular sacral-distribution pain (zoster sine herpete), cervical-distribution zoster paresis and thoracic-distribution myelopathy. Detection of anti-varicella zoster virus (VZV) IgM and VZV IgG antibody in cerebrospinal fluid (CSF), with reduced serum/CSF ratios of anti-VZV IgG compared to normal serum/CSF ratios for albumin and total IgG, proved that VZV caused the protracted neurological complications. Diagnosis by antibody testing led to aggressive antiviral treatment and a favorable outcome.

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