Affordable Access

Publisher Website

The significance of serum xanthine oxidase and oxidation markers in acute paraquat poisoning in humans

Authors
Journal
Clinical Biochemistry
0009-9120
Publisher
Elsevier
Publication Date
Volume
44
Identifiers
DOI: 10.1016/j.clinbiochem.2010.09.006
Keywords
  • Oxidative Stress
  • Xanthine Oxidase
  • Superoxide Dismutase
  • Glutathione Malondialdehyde
  • Paraquat Poisoning

Abstract

Abstract Objectives Determine xanthine oxidase (XO) activity and oxidative-stress parameters in human acute paraquat poisoning. Design and methods Twnty-five patients and 26 healthy control participants were recruited. Serum XO, superoxide dismutase (SOD), Glutathione (GSH) and malondialdehyde (MDA) were determined by spectrophotometric methods. Results XO activity and MDA levels were higher and SOD activity and GSH level were lower in the patients group. XO activity and MDA level were significantly higher, and the GSH level and SOD activity were lower in the paraquat poisoning fatality group. There was a significant negative correlation between the XO activity and both the SOD and GSH, while there was a significant positive correlation between XO activity and the MDA level in the patients group. Conclusions XO activity contributes to the development of oxidative injury in patients with paraquat poisoning. Serum XO activity could be used as a marker for prognosis in human acute paraquat intoxication.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

The significance of the measurement of serum xanth...

on The Journal of international m... 2010

[Significance of determination of serum xanthine o...

on Zhonghua lao dong wei sheng zh... April 2008

[Prognostic significance of serum lactic acid in e...

on Zhonghua wei zhong bing ji jiu... September 2013

Xanthine oxidase is increased and contributes to p...

on Journal of Applied Physiology April 1990
More articles like this..