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Preconditioning Therapy with Lentiviral Vector-Programmed Dendritic Cells Accelerates the Homeostatic Expansion of Antigen-Reactive Human T Cells in NOD.Rag1−/−.IL-2rγc−/− mice

Authors
Journal
Human Gene Therapy
1043-0342
Publisher
Mary Ann Liebert
Publication Date
Volume
22
Issue
10
Identifiers
DOI: 10.1089/hum.2010.215
Keywords
  • Research Articles

Abstract

Salguero and colleagues show proof of concept that preconditioning hosts with lentiviral vector-programmed dendritic cells expressing a viral antigen before T cell infusion accelerates T cell engraftment, biodistribution, and stimulation of antigen-specific immune responses in permissive mice.

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