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Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals

Authors
  • Wefers, Jakob1
  • Connell, Niels J.1
  • Fealy, Ciarán E.1
  • Andriessen, Charlotte1
  • de Wit, Vera1
  • van Moorsel, Dirk2
  • Moonen-Kornips, Esther1
  • Jörgensen, Johanna A.1
  • Hesselink, Matthijs K.C.1
  • Havekes, Bas1, 2
  • Hoeks, Joris1
  • Schrauwen, Patrick1
  • 1 Department of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, the Netherlands
  • 2 Division of Endocrinology, Department of Internal Medicine, Maastricht University Medical Center, 6200 MD Maastricht, the Netherlands
Type
Published Article
Journal
Molecular Metabolism
Publisher
Elsevier BV
Publication Date
Jul 11, 2020
Volume
41
Identifiers
DOI: 10.1016/j.molmet.2020.101050
PMID: 32659272
PMCID: PMC7415921
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Diurnal rhythmicity of mitochondrial function is attenuated in older and metabolically compromised men. • Rhythmicity of the biological clock gene PER2 is disturbed in skeletal muscle of these volunteers. • Metabolic flexibility in 24-h metabolism is diminished, with a lack of a typical feeding-fasting cycle.

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