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Daunorubicin accumulation by human myeloblasts varying in anthracycline resistance.

Authors
  • Kessel, D
  • Wilberding, C
  • Karanes, C
  • Ratanatharathorn, V
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Oct 01, 1984
Volume
24
Issue
3
Pages
305–309
Identifiers
PMID: 6594191
Source
Medline
License
Unknown

Abstract

Circulating myeloblasts were obtained from patients with acute myelogenous leukemias varying widely in anthracycline responsiveness. Studies were carried out in vitro to assess the capacity of such cells for daunorubicin accumulation. There was no correlation between drug responsiveness patterns in vivo vs. drug transport phenomena measured in vitro. A mode of enhanced anthracycline exodus demonstrable in certain drug-resistant murine leukemia cell lines could not be detected in the drug-resistant human myeloblasts.

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