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Daily Cannabis Users with Sickle Cell Disease Show Fewer Admissions than Others with Similar Pain Complaints

Authors
  • Curtis, Susanna A.1
  • Brandow, Amanda M.2
  • DeVeaux, Michelle3
  • Zeltermam, Daniel4
  • Devine, Lesley1
  • Roberts, John D.1
  • 1 Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut.
  • 2 Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.
  • 3 Department of Early Clinical Development, Regeneron Pharmaceuticals, Tarrytown, New York.
  • 4 Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut.
Type
Published Article
Journal
Cannabis and Cannabinoid Research
Publisher
Mary Ann Liebert, Inc., publishers
Publication Date
Sep 02, 2020
Volume
5
Issue
3
Pages
255–262
Identifiers
DOI: 10.1089/can.2019.0036
PMID: 32923662
PMCID: PMC7480712
Source
PubMed Central
Keywords
License
Unknown

Abstract

Introduction: Previous studies have shown that cannabis use is common in adults with sickle cell disease (SCD), and that many patients report using cannabis to treat pain. Methods: We performed a cross-sectional study of adults with SCD and compared daily users of cannabis with others using validated patient-reported measures of pain and quality of life as well as opioid and health care utilization. Results: Daily cannabis users with SCD had worse pain episode severity scores than others (56.7 vs. 48.8, p =0.02) yet had 1.8 fewer annual admissions ( p =0.01) and 1.2 fewer annual emergency room (ER) visits ( p =0.01), and similar amounts of opioids dispensed to others after matching for age, gender, SCD genotype, hydroxyurea use, and pain impact scores. Conclusions: We show that people with SCD with more severe pain crisis are more likely to use daily cannabis, yet have lower rates of hospital admission and ER use as compared with others with similar disease severity and pain impact. Randomized controlled trials should be performed.

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