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Cholesterol and serotonin indices in depressed and suicidal patients

Authors
Journal
Journal of Affective Disorders
0165-0327
Publisher
Elsevier
Publication Date
Volume
62
Issue
3
Identifiers
DOI: 10.1016/s0165-0327(99)00200-1
Keywords
  • Depression
  • Suicide
  • Cholesterol
  • D-Fenfluramine
  • Serotonin

Abstract

Abstract Background: Prolactin and cortisol responses to d-fenfluramine challenge of central serotonin are reduced in depressed and suicidal patients. Low serum cholesterol levels are also reported in suicidal behavior. Thus, we examined for a relationship between serum cholesterol and fenfluramine challenge responses in patients with depression and/or attempted suicide. Methods: We studied 12 patients and six controls. Blood was drawn for baseline serum cholesterol and the d-fenfluramine challenge test performed. Results: Serum cholesterol levels were significantly lower in suicidal patients than in either non-suicidal patients or controls. However, neither the prolactin nor cortisol responses to d-fenfluramine correlated significantly with serum cholesterol levels. Conclusion: No relationship was found between serum cholesterol and these peripheral indices of serotonergic function.

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