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A practical route to enantiopure 1,2-aminoalcohols

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
37
Issue
19
Identifiers
DOI: 10.1016/0040-4039(96)00534-5

Abstract

Abstract A series of enantiopure aminoalcohols were synthesized from the corresponding diols by activation of the diols as cyclic carbonates, azide opening of the carbonates, and hydrogenation of the resulting azidoalcohols. Factors affecting the azide opening of the carbonates, a simple workup procedure, and a large scale synthesis of (1R,2S)-(−)-2-amino-1,2-diphenylethanol are described.

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