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Mixed micelle systems formed from critical micelle concentration and temperature-sensitive diblock copolymers for doxorubicin delivery

Authors
Journal
Biomaterials
0142-9612
Publisher
Elsevier
Publication Date
Volume
30
Identifiers
DOI: 10.1016/j.biomaterials.2009.04.002
Keywords
  • Mixed Micelle
  • Cmc Diblock Copolymer
  • Temperature-Sensitive Diblock Copolymer
  • Micellar Stability
  • Drug Delivery
Disciplines
  • Biology
  • Chemistry

Abstract

Abstract Mixed micelles formed by critical micelle concentration (Cmc) character's diblock copolymer, and temperature-sensitive character's diblock copolymer were studied for their capabilities in improving stability with and without drug. Experimental results showed that this type of mixed micellar systems possessed complementary effects in adjusting external temperature shift (storage vs. body temperature) and concentration change (dilution after intravenous injection). Therefore, they provided excellent stability as drug carriers. Further results obtained from physicochemical property and drug release kinetics studies demonstrated such systems could also be applied to physiological conditions, in compliance with varied pH environments. We concluded that the newly developed mixed micelles can serve as a potential injectable drug delivery system for anticancer drugs, such as doxorubicin and many others.

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