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Expression of interleukin 6 in synovial tissues in patients with internal derangement of the temporomandibular joint

Authors
Journal
British Journal of Oral and Maxillofacial Surgery
0266-4356
Publisher
Elsevier
Publication Date
Volume
41
Issue
2
Identifiers
DOI: 10.1016/s0266-4356(02)00294-2
Disciplines
  • Chemistry

Abstract

Abstract Using an immunohistochemical technique, we examined synovial tissue from 46 temporomandibular joints (TMJ) with internal derangement in 44 patients. As controls, we examined synovial tissue specimens from 7 joints with habitual dislocation without pain. In synovial tissues from 21 of the 46 joints with internal derangement, interleukin 6 (IL-6) was expressed in the synovial lining cells and in the mononuclear cells infiltrating the periphery of the blood vessels. The density of IL-6-stained cells in specimens with internal derangement correlated significantly with the grade of joint effusion shown by magnetic resonance imaging ( P=0.01, r=0.32).

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