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Differences in the molecular weight profile of poloxamer 407 affect its ability to redirect intravenously administered colloids to the bone marrow

Authors
Journal
International Journal of Pharmaceutics
0378-5173
Publisher
Elsevier
Publication Date
Volume
83
Identifiers
DOI: 10.1016/0378-5173(82)90033-3
Keywords
  • Bone Marrow
  • Microsphere
  • Poloxamer 407
  • Rabbit
  • Rat

Abstract

Abstract Samples of poloxamer 407 obtained from different suppliers have been assessed for their ability to redirect model polystyrene colloids to the bone marrow in rabbits. Only poloxamer 407 obtained from one supplier was found to produce the targeting effect seen previously. The variation in the biodistribution patterns produced by the different samples of poloxamer 407 may by caused by differences in the molecular weight distribution of the polymer.

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