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The effects of ligature of the thoracic duct on serum and liver lipids in normotensive and hypertensive rats

Authors
Journal
Atherosclerosis
0021-9150
Publisher
Elsevier
Publication Date
Volume
18
Issue
3
Identifiers
DOI: 10.1016/0021-9150(73)90066-x
Keywords
  • Ligature Of The Thoracic Duct
  • Liver Lipids
  • Morphological Alterations
  • Renal Hypertension
  • Serum Lipids

Abstract

Abstract After development of an experimentally induced renal hypertension in rats, elevated concentrations of cholesterol and phospholipids in serum were observed. The additional ligature of the thoracic duct in normotensive and hypertensive animals further increased the lipid content of serum in hypertensive rats and promoted an even more severe hyperlipaemia in normotensive animals. In both experimental groups the hyperlipaemia took a biphasic course. The lipids measured approached their intitial values on the 15th day following the ligature of the ductus thoracicus. Moreover the ligature of the thoracic duct modified the total lipid content of the liver and induced pronounced morphological alterations of liver tissue.

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