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The expression of hTR and hTERT in human breast cancer: correlation with clinico-pathological parameters

BioMed Central
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Abstract ral International Seminars in Surgical ss BioMed CentOncology Open AcceResearch The expression of hTR and hTERT in human breast cancer: correlation with clinico-pathological parameters Saied Hosseini-Asl1, Morteza Atri2, Mohammad H Modarressi1, Mohamed Salhab3, Kefah Mokbel3 and Parvin Mehdipour*1 Address: 1Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, IR, Iran, 2Cancer Institute, Tehran University of Medical Sciences/Day General Hospital, Tehran, IR, Iran and 3St George's Hospital, London, SW17 0QT, UK Email: Saied Hosseini-Asl - [email protected]; Morteza Atri - [email protected]; Mohammad H Modarressi - [email protected]; Mohamed Salhab - [email protected]; Kefah Mokbel - [email protected]; Parvin Mehdipour* - [email protected] * Corresponding author Abstract Background: Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalization. Telomerase has been associated with negative prognostic indicators in some studies. The present study aims to detect any association between telomerase sub-units: hTERT and hTR and the prognostic indicators including tumour's size and grade, nodal status and patient's age. Methods: Tumour samples from 46 patients with primary invasive breast cancer and 3 patients with benign tumours were collected. RT-PCR analysis was used for the detection of hTR, hTERT, and PGM1 (as a housekeeping) genes expression. Results: The expression of hTR and hTERT was found in 31(67.4%) and 38 (82.6%) samples respectively. We observed a significant association between hTR gene expression and younger age at diagnosis (p = 0.019) when comparing patients ≤ 40 years with those who are older than 40 years. None of the benign tumours expressed hTR gene. However, the expression of hTERT gene was revealed in 2 samples. No significant association between hTR and h

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