Affordable Access

Publisher Website

Acute cold-restraint stress affectsα2-adrenoceptors in specific brain regions of the rat

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
401
Issue
1
Identifiers
DOI: 10.1016/0006-8993(87)91159-0
Keywords
  • α2-Adrenoceptor
  • Restraint Stress
  • Receptor Modulation
  • [3H]Rauwolscine
  • Radioligand Binding Assay
  • Rat Brain

Abstract

Abstract The effect of acute cold-restraint stress on binding of [ 3H]rauwolscine to α 2-adrenoceptors was investigated in 10 regions of rat brain. Acute stress: (1) significantly decreased the density but had no significant effect on the affinity of binding sites in the hippocampus; (2) decreased density and increased affinity in the amygdala; and (3) increased density and decreased the affinity in the midbrain. Seven other brain regions showed no significant changes in binding parameters in response to stress. These results, together with previous findings in this laboratory showed that alteration by restraint stress of noradrenaline levels in amygdala and hippocampus, but not other regions, indicate an association between neurotransmitter turnover and receptor function.

There are no comments yet on this publication. Be the first to share your thoughts.