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Potential diagnostic implications of breakpoints in the long arm of chromosome 8 in lipoblastoma

Authors
Journal
Cancer Genetics and Cytogenetics
0165-4608
Publisher
Elsevier
Publication Date
Volume
76
Issue
1
Identifiers
DOI: 10.1016/0165-4608(94)90068-x

Abstract

Abstract We report a case of lipoblastoma in a 17-month-old male patient with a pseudodiploid karyotype of 46,XY,der(14)t(8;14)(q11.2;q24). The tumor cells show two normal chromosome 8 homologs in addition to the extra 8q11.2→qter segment, making it trisomic for the region 8q11.2→qter, and monosomic for 14q24→qter. Reports of chromosome studies in lipoblastoma are rare; however, a breakpoint in the long arm of chromosome 8q11–13 appears to be emerging as a consistent finding.

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