Abstract Arsenic and copper contents were estimated in 22 liver specimens of alcohol-related liver disease, out of which eleven were proved histologically of alcoholic cirrhosis. Significantly high amounts of arsenic and copper could be detected in these livers. Various surveys were conducted in different places to find the cause of high arsenic and copper in patients of alcoholic cirrhosis. It was found that persons in our subcontinent consume a ‘home made brew’. When fourteen samples of such liquors were analysed, they were found to contain high levels of arsenic.