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Signal Transduction: RABGEF1 Fingers RAS for Ubiquitination

Authors
Journal
Current Biology
0960-9822
Publisher
Elsevier
Publication Date
Volume
20
Issue
15
Identifiers
DOI: 10.1016/j.cub.2010.06.019
Disciplines
  • Biology

Abstract

Summary RAS proteins conduct signaling from surface receptors to cytoplasmic effectors, and RAS gain-of-function mutations are pervasive in cancer. A new mechanism for RAS signal attenuation with implications for receptor trafficking has been uncovered.

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