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Polyploidy and Radiosensitive Behaviour of Human Malignant Cells In Vivo

British Journal of Cancer
Nature Publishing Group
Publication Date
  • Articles
  • Medicine


54 POLYPLOIDY AND RADIOSENSITIVE BEHAVIOUR OF HUMAN MALIGNANT CELLS IN VIVO N. DE From the Department of Cell Research, Chittaranjan National Cancer Research Centre, Calcutta 26, India Received for publication January 10, 1961 IT is an established fact that malignant cells of the same type under the same radiation treatment react differently to the therapy. Goldfeder (1947) has shown that malignant cells ofthe same morphological type differ in radiosensitivity. Koller (1947) has also show-n that the mean number of chromosome fragments per cell differs in cell samples taken from different regions of the same tumour after radi- ation treatment. In plant material, different authors have observed different types of correlation between polyploidy and radiosensitivity of normal cells. Smith (1946) and Bishop (1952) reported that the sensitivity of the polyploid cells is equal to that of diploids. Sax and Swanson (1941), Froier, Gustafsson and Tedin (1942), Sparrow (1957) and Oster (1958) are of the opinion that a high degree of radioresistance of normal cells is related to their high chromosome number. Puck (1960) demonstrated that in vitro, hyperploid and aneuploid normal human cells are more radioresistant than diploid cells. Revesz and Norman (1960) have made a correlation study of chromosomal ploidy and radiosensitive behaviour of the ascites tumour cell population. As the majority of malignant tissues of human patients are in solid form, so ultimate radiotherapeutic assessment should be made on solid tumour. Atkin, Richards and Ross (1959) and Richards and Atkin (1959) have made a study of some possible significance of radiotherapeutic effect and DNA content of different types of solid tumour arising from human uterus. They have suggested (Atkin et al., 1959) that radioresistant cell strains are more often higher than diploid than near diploid. The present investigation was undertaken to study the relationship between the chromosomal population and radiosensitivity ofepidermoid carcinoma ce

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