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Levetiracetam-loaded biodegradable polymer implants in the tetanus toxin model of temporal lobe epilepsy in rats

Authors
Journal
Journal of Clinical Neuroscience
0967-5868
Publisher
Elsevier
Volume
20
Issue
1
Identifiers
DOI: 10.1016/j.jocn.2012.05.017
Keywords
  • Biodegradable
  • Drug Delivery
  • Epilepsy
  • Implantable Devices
  • Levetiracetam
  • Polymer
  • Tetanus Toxin
Disciplines
  • Medicine

Abstract

Abstract Approximately one-third of people with epilepsy receive insufficient benefit from currently available anticonvulsant medication, and some evidence suggests that this may be due to a lack of effective penetration into brain parenchyma. The current study investigated the ability of biodegradable polymer implants loaded with levetiracetam to ameliorate seizures following implantation above the motor cortex in the tetanus toxin model of temporal lobe epilepsy in rats. The implants led to significantly shorter seizures and a trend towards fewer seizures for up to 1week. The results of this study indicate that drug-eluting polymer implants represent a promising evolving treatment option for intractable epilepsy. Future research is warranted to investigate issues of device longevity and implantation site.

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