Affordable Access

Publisher Website

Sequential loss of outer membrane lipopolysaccharide and sensitivity ofEscherichia colito antibacterial agents

Authors
Journal
International Journal of Pharmaceutics
0378-5173
Publisher
Elsevier
Publication Date
Volume
35
Issue
3
Identifiers
DOI: 10.1016/0378-5173(87)90134-7
Keywords
  • Antibacterial Agent
  • Escherichia Coli
  • Lipopolysaccharide (Lps) Mutant
  • Edta
  • Phenolic
  • Paraben

Abstract

Abstract The effects of 3 phenolics and of a homologous series of esters of para-hydroxybenzoic acid (the parabens) on Escherichia coli with known deletions in outer membrane lipopolysaccharide (LPS) are described. Of the phenolics, chlorocresol was the most active and phenol the least, with butyl p-hydroxybenzoate the most effective paraben. The most sensitive strain to the various inhibitors was usually a deep rough mutant (heptoseless LPS). Studies were also made with a chelating agent, ethylenediamine tetraacetate (EDTA) in combination with some parabens. EDTA potentiated, to some extent, the activity of the methyl and butyl esters, its activity depending upon the concentration at which it was employed.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Electron spin resonance probing of lipopolysacchar...

on Biochimica et Biophysica Acta... Jan 01, 1983

Stimulation by lipopolysaccharide of the binding o...

on Biochemical and Biophysical Re... Jan 01, 1977

Biosynthesis and structure of lipopolysaccharide i...

on Biochimica et Biophysica Acta... Jan 01, 1977

Sensitivity of DNA-repair-deficient strains ofEsch...

on Mutation Research Letters Jan 01, 1986
More articles like this..