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Survival after Lung Transplantation Is Linked with a Genetic Polymorphism in Caveolin-1

Authors
Journal
The Journal of Heart and Lung Transplantation
1053-2498
Publisher
Elsevier
Volume
32
Issue
4
Identifiers
DOI: 10.1016/j.healun.2013.01.259
Disciplines
  • Biology
  • Medicine

Abstract

Purpose Caveolin 1 (Cav-1) is a structural protein of the cell membrane invaginations, important in tissue homeostasis. Expression of Cav-1 is involved in pulmonary inflammation and fibrosis. Therefore we investigated in our lung transplant cohort the influence of Cav-1 polymorphism on acute and chronic rejection, respiratory infection rate and survival after lung transplantation. Methods and Materials Recipient DNA from blood or explant lung tissue was collected and investigated for the Cav-1 (rs3807989) polymorphism by iPLEX technology on a MassARRAY and paralleled with patient information available in our database regarding the mentioned outcome parameters. Results Of all 568 LTx patients, Cav-1 SNP (rs3807989) was successfully determined in 503 patients of which 92 had the AA genotype (18.3%), 234 had the AG genotype (46.5%) and 177 had the GG genotype (35.2%). The A allele (AA+AG) was linked with a higher mortality (p=0.017), but in contrast no difference in chronic rejection (p=0.80). [figure 1] The GG genotype group experienced more lymphocytic bronchitis (LB) (p=0.0087); however, there was no significant difference in acute rejection (p=0.13). In the allele at risk, a trend for an increased prevalence of respiratory infections was present (p=0.056). [figure 2] Conclusions Within our lung transplant cohort, patients with the A-allele in CAV-1 are more prone to develop respiratory infections and death, despite a lower number of LB events.

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