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The administration of triiodothyronine to rats results in a lowering of the mitochondrial membrane potential in isolated hepatocytes

Authors
Journal
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
0167-4889
Publisher
Elsevier
Publication Date
Volume
1133
Issue
1
Identifiers
DOI: 10.1016/0167-4889(91)90245-s
Keywords
  • Hepatocyte
  • Thyroid Hormone
  • Membrane Potential
  • (Rat Liver)

Abstract

Abstract Although thyroid status has been shown to influence the magnitude of the membrane potential in isolated rat-liver mitochondria, there is variation in the reported size and direction of the thyroid hormone-induced change relative to the normal state. Measurement of the mitochondrial membrane potential is intact hepatocytes isolated from hyperthyroid and euthyroid rats reveals that hyperthyroidism results in a decrease of approximately 30 mV in the magnitude of this potential relative to that in the euthyroid state. As well, the magnitude of the plasma membrane potential of hepatocytes from hyperthyroid rats is reduced by 6 mV compared with that in cells from euthyroid rats. The thyroid hormone-induced decrease in these potentials may reflect reported changes in the lipid composition of the membranes.

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