Affordable Access

Publisher Website

Prevalence ofTEL/AML1fusion gene in Brazilian pediatric patients with acute lymphoblastic leukemia

Cancer Genetics and Cytogenetics
Publication Date
DOI: 10.1016/j.cancergencyto.2003.09.003
  • Medicine


Abstract We studied 58 childhood B-lineage acute lymphoblastic leukemia (B-ALL) in Brazilian sample patients at the time of diagnosis to investigate the prevalence of the cryptic t(12;21)(p13;q22). All bone marrow specimens were G-band karyotyped, and commercial dual-color DNA probes were used to search for fusion signals in nuclei. The karyotype analysis showed hyperdiploidy as the most frequent abnormality. The frequency of patients with TEL/AML1 gene fusion was 19% (11 out of 58 cases). Six of the positive samples had normal karyotypes. Deletion of the wild-type TEL allele was observed in 27.3% of TEL/AML1 fusion–positive cases, but it was also identified in 4.2% of the negative cases. Three cases presented two fusion signals, indicating possible duplication of the der(21). The mean age of the patients with TEL/AML1 fusion was 4.8 years and the mean amount of peripheral leukocytes was 44,270×10 6/L. The higher frequency of females with B-ALL (33/58 cases) observed in our sample was probably due to the selection mode of the study cases. The prevalence of TEL/AML1 fusion in Brazilian children in our study is similar to that found in other populations.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Prevalence of TEL/AML1 fusion gene in Brazilian pe...

on Cancer Genetics and Cytogeneti... May 2004

A fluorescence in situ hybridization study ofTEL-A...

on Cancer Genetics and Cytogeneti... Jan 01, 2003

Low frequency ofTEL/AML1in adult acute lymphoblast...

on Cancer Genetics and Cytogeneti... Jan 01, 1997

The presence ofTEL/AML1rearrangement and cryptic d...

on Cancer Genetics and Cytogeneti... Jan 01, 2005
More articles like this..