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Ethanol increases synaptosomal free calcium concentration

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
89
Issue
2
Identifiers
DOI: 10.1016/0304-3940(88)90375-8
Keywords
  • Ethanol
  • Synaptosome
  • Free Calcium
  • Fura-2
  • 45Ca2+Uptake

Abstract

Abstract The effect of ethanol on synaptosomal free calcium concentration ([Ca 2+] i) and 45Ca 2+ uptake was studied in vitro. Synaptosomes were prepared from forebrains of adult rats and incubated in the presence of ethanol 50 500 mM. [Ca 2+] i determined by means of the Ca 2+-sensitive dye, fura-2, was increased by ethanol in polarized and depolarized synaptosomes, whereas 45Ca 2+ uptake was decreased. The results suggest that ethanol may influence neuronal calcium homeostasis by increasing rather than decreasing [Ca 2+] i.

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