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DNA-mediated transfer of actinomycin D resistance into cultured mouse cells

Authors
Journal
Experimental Cell Research
0014-4827
Publisher
Elsevier
Publication Date
Volume
156
Issue
2
Identifiers
DOI: 10.1016/0014-4827(85)90562-2
Disciplines
  • Biology

Abstract

Abstract The transfer of high molecular weight (HMW) DNA isolated from Syrian hamster actinomycin D-resistant cells (C12TSV5/R) to sensitive A9 mouse cells, resulted in the growth in selective medium of transferent clones A9 ActR Cl1, Cl1, and Cl3). The resistant mouse cells have presumably acquired a gene(s) conferring actinomycin D resistance and express a 140–150 K surface glycoprotein, apparently involved in the drug resistance.

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