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Changes inα1-adrenergic neurotransmission alter the number of somatostatin receptors in the rat hippocampus

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
177
Identifiers
DOI: 10.1016/0304-3940(94)90056-6
Keywords
  • Phenylephrine
  • Prazosin
  • Somatostatin Receptor
  • Adenylyl Cyclase
  • Hippocampus
  • Rat

Abstract

Abstract The administration of an i.p. dose of phenylephrine (2 mg/kg) increased the number of [ 125I]Tyr 11-somatostatin ([ 125I]Tyr 11-SS) receptors and decreased their apparent affinity in rat hippocampal membranes 7 h after its injection. Prazosin (20 mg/kg, i.p.) administered 1 h before phenylephrine reversed effects of the latter on SS binding. Prazosin alone decreased the number of SS receptors without changing the affinity. The addition of phenylephrine or prazosin (10 −5 M) to the incubation medium did not change the SS binding characteristics. The present results support the notion that the α 1-adrenergic system regulates the binding of SS to its specific receptors in rat hippocampus.

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