Affordable Access

Publisher Website

Involvement of the Snk-SPAR pathway in glutamate-induced excitotoxicity in cultured hippocampal neurons

Authors
Publisher
Elsevier B.V.
Publication Date
Volume
1168
Identifiers
DOI: 10.1016/j.brainres.2007.06.082
Keywords
  • Serum-Induced Kinase
  • Spine-Associated Rap Gtpase-Activating Protein
  • Dendritic Spine
  • Glutamate
  • Mk801
Disciplines
  • Biology

Abstract

Abstract The serum-induced kinase (Snk)–spine-associated Rap GTPase-activating protein (SPAR) signaling pathway is reported as a new molecular mechanism in activity-dependent remodeling of synapses. However, the relationship between Snk-SPAR pathway and glutamate-induced excitotoxicity is not well understood. We report here that in cultured hippocampal neurons, glutamate stimulation induces the activation of Snk-SPAR pathway, and leads to a loss of mature dendritic spines. The time-dependent changes in Snk and SPAR expression after glutamate exposure are also elucidated. Furthermore, the activation of Snk-SPAR pathway induced by glutamate treatment can be blocked by an NMDA receptor antagonist, MK801. These results demonstrate that Snk-SPAR pathway may play a pivotal role in glutamate-induced exicitotoxic damage in CNS through regulating the stability of synapse.

There are no comments yet on this publication. Be the first to share your thoughts.