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Transcription factor binding variation in the evolution of gene regulation

Authors
Journal
Trends in Genetics
0168-9525
Publisher
Elsevier
Publication Date
Volume
26
Issue
11
Identifiers
DOI: 10.1016/j.tig.2010.08.005
Disciplines
  • Biology

Abstract

Transcription factor interactions with DNA are one of the primary mechanisms by which expression is modulated, yet their evolution remains poorly understood. Chromatin immunoprecipitation followed by microarray (ChIP-chip) or sequencing (ChIP-Seq) has revolutionized the study of protein–DNA interactions. However, only recently has attention focused on determining to what extent these regulatory interactions vary between species across entire genomes. A series of recent studies have compared in vivo binding data across a range of evolutionary distances. Binding events diverge rapidly, indicating gene regulation is an evolutionarily flexible process.

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