Affordable Access

Publisher Website

Environmental crowding modifies responding to noxious stimuli and the effects of μ- and k-agonists

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
31
Identifiers
DOI: 10.1016/0024-3205(82)90345-9

Abstract

Abstract The effects of social crowding in rats on nociception and analgesic actions of μ- and k-opioid agonists against qualitatively different stimuli were examined. Crowding produced higher control thresholds for electroshock and paw pinch pressure but not for noxious heat. Naloxone did not effect shock thresholds in crowded or noncrowded rats but it produced hyperalgesia in both groups when pressure and heat were the stimuli. Crowding reduced the antinociceptive potency against pressure of k- and μ-agonists but the opposite effect was seen with heat. A comparison of the ratios of potencies against pressure and heat indicates that crowding differentially modified k- and μ-receptor systems.

There are no comments yet on this publication. Be the first to share your thoughts.