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The acceleration of hepatic regeneration by prior laparotomy

Authors
Journal
Journal of Surgical Research
0022-4804
Publisher
Elsevier
Publication Date
Volume
23
Issue
5
Identifiers
DOI: 10.1016/0022-4804(77)90066-x

Abstract

Abstract Laparotomy, carried out 6 hr prior to partial hepatectomy, accelerates the initial rise and first peak of DNA synthesis by approximately 3 hr and the second peak by approximately 6 hr in the rat model. The effect is most striking in the 16-hr postresection liver in which [ 3H]thymidine incorporation in animals stressed by prior laparotomy was >25 times that found in unstressed animals. These studies suggest that an initial phase of the response to hepatic resection may be initiated by nonspecific trauma which is of sufficient magnitude and administered at an appropriate interval prior to hepatectomy.

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