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Oligonucleotide synthesis as a tool in drug discovery research

Authors
Journal
Drug Discovery Today
1359-6446
Publisher
Elsevier
Publication Date
Volume
3
Issue
1
Identifiers
DOI: 10.1016/s1359-6446(97)01116-1
Disciplines
  • Pharmacology

Abstract

Facile methods for oligonucleotide synthesis have been responsible for the development of several enabling technologies, thereby creating new opportunities in pharmaceutical R&D. It has therefore become necessary for successful drug discovery enterprises to be well versed in the rapid synthesis and distribution of oligonucleotides. To achieve this goal, automated DNA synthesizers have been coupled with downstream automated workstations and a relational database to keep track of all aspects of the oligonucleotide production process. The use of the workstation approach allows for the rapid synthesis, purification, analysis and distribution of oligonucleotides and their analogs.

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