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A double-blind comparison of fluvoxamine, imipramine and placebo in depressed patients

Authors
Journal
Journal of Affective Disorders
0165-0327
Publisher
Elsevier
Publication Date
Volume
7
Identifiers
DOI: 10.1016/0165-0327(84)90051-x
Keywords
  • Depression
  • Double-Blind Study
  • Fluvoxamine
  • Imipramine
  • Placebo

Abstract

Abstract In a placebo-controlled, double-blind study of 91 out-patient depressives, the anti-depressant effect of fluvoxamine, a selective serotonin uptake inhibitor was compared to that of imipramine. Overall drug effects were relatively weak but analyses in selected sub-groups showed both active drugs superior to placebo. Effects of fluvoxamine were more marked in non-situational depressives and it did not improve sleep while effects of imipramine were more marked in retarded depressives and on retardation ratings, suggesting that fluvoxamine may have a different pattern of clinical effects. Side effects of Fluvoxamine were predominantly gastrointestinal and it did not produce postural hypotension or anticholinergic side-effects.

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