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A novel myeloid cell line, Marimo, derived from therapy-related acute myeloid leukemia during treatment of essential thrombocythemia: Consistent chromosomal abnormalities and temporaryC-MYCgene amplification

Authors
Journal
Cancer Genetics and Cytogenetics
0165-4608
Publisher
Elsevier
Publication Date
Volume
100
Issue
1
Identifiers
DOI: 10.1016/s0165-4608(97)00017-4
Disciplines
  • Medicine

Abstract

Abstract A novel myeloid leukemia cell line, Marimo, was established from bone marrow cells of a patient with secondary acute myeloid leukemia (AML) that had developed during the treatment of essential thrombocythemia (ET) with busulfan. Karyotype at the ET phase was 46,XX,der(15)t(1;15) (q23;p12–13), but at the blastic phase changed to 44,XX,−5,de1(8)(q22),add(17)(p11),+18, psu dic(18;9) (q23;p21)x2 lacking t(1;15). In Marimo cells, C-MYCgene was temporarily amplified by double-minutes (dmin) but disappeared at 33 months, whereas t(10;14;11)(q22;q32;q13) and t(10;14)(q22;q32) were added in vitro psu dic(18;9)×2 and add(17)(p11) were consistently found throughout the culture. These results suggest that this AML clone is not derived from ET but rather is therapy-related.

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