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Serotonin receptor activation enhances neurite outgrowth of thalamic neurones in rodents

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
269
Issue
2
Identifiers
DOI: 10.1016/s0304-3940(99)00422-x
Keywords
  • Serotonin
  • Neurite Outgrowth
  • Thalamic Neurones
  • Rodent Barrel Field
Disciplines
  • Chemistry

Abstract

Abstract Serotonin (5-HT) has been shown to influence the development of the rodent barrel field by affecting the patterning of thalamic axons in the somatic sensory cortex. To determine whether this is a direct effect on thalamocortical neurones, we analyzed primary thalamic cultures taken from E15 mouse embryos. We show that 5-HT enhances neurite outgrowth of thalamic neurones. The sodium channel blocker, TTX, blocks these effects, whereas the selective 5-HT1B agonist CGS-12066A maleate reproduced 5-HT's effect. Using PCR and immunocytochemistry, we found that 5-HT1B receptors are already expressed by thalamic neurones at E15, and that this expression is maintained in vitro. These results suggest that 5-HT-1B receptor activation directly affects the growth of thalamocortical axons.

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