Affordable Access

Publisher Website

Vision tests in the mouse: Functional phenotyping with electroretinography.

Authors
Journal
Frontiers in Bioscience
1093-9946
Publisher
Frontiers in BioScience
Publication Date
Identifiers
DOI: 10.2741/3409
Keywords
  • Animals
  • Electroretinography
  • Flicker Fusion
  • Mice
  • Mice
  • Inbred C57Bl
  • Vision Tests
Disciplines
  • Biology
  • Engineering
  • Medicine

Abstract

Electroretinography (ERG) is an established diagnostic technique in clinical ophthalmology and provides objective information about retinal function. This technique is also applied in basic research, where animal models of hereditary retinopathies have significantly contributed to our understanding of the composition of ERG responses in general and how retinal degenerative pathologies alter retinal function specifically. Indeed, electrophysiologic assessment of transgenic mice, which are genetically engineered to mimic human mutations that lead to retinal diseases, can be well compared with clinical data. Furthermore, limitations on examinations (e.g. length of measurement, range of light intensity) are much less of a concern when assessing mice compared to human patients. In order to measure and analyze retinal responses properly, several important aspects have to be considered. This paper focuses on these aspects, and shows exemplary ERG data which were obtained from normal wild-type mice and from transgenic mice with specific functional properties, namely Rho-/- (rod opsin knockout, cone function only), and Cnga3-/- (cone CNG channel deficient, rod function only) to illustrate rod and cone system contributions to ERG responses.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Vision tests in the mouse: Functional phenotyping...

on Frontiers in bioscience (Landm... 2009

Functional phenotyping of mouse models with ERG.

on Methods in Molecular Biology 2013

Mouse phenotyping.

on Methods February 2011

[Dynamic electroretinography in the normal subject...

on La Médecine aéronautique 1959
More articles like this..