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Chemotherapy of advanced breast cancer:Results of a controlled trial comparing two three-drug regimens

Authors
Journal
European Journal of Cancer (1965)
0014-2964
Publisher
Elsevier
Publication Date
Volume
14
Issue
9
Identifiers
DOI: 10.1016/0014-2964(78)90017-8
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Seventy patients with breast cancer in an advanced stage were treated, at random, according to one of the two regimens of cyclic administration, associating, on one hand, doxorubicin + vincristine + methotrexate and on the other hand, vincristine + cyclophosphamide + 5 fluorouracil. Only the immediate results are studied in this controlled trial in 61 evaluable patients. They are significantly better with the first association: 63% measurable objective responses vs 47.5% (0.025 < P < 0.05) and 30% of tumoral regressions superior to 50% vs 3.2% (0.001 < P < 0.010). The toxicity is hardly more marked (mainly cardiovascular and hematological) in the second regimen than in the first one, but remains altogether acceptable for an induction chemotherapy.

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