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BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.

Authors
Journal
Journal of Experimental Medicine
0022-1007
Publisher
The Rockefeller University Press
Publication Date
Volume
189
Issue
11
Identifiers
DOI: 10.1084/jem.189.11.1747
Keywords
  • Amino Acid Sequence
  • Animals
  • B-Cell Activating Factor
  • B-Lymphocytes/Cytology
  • B-Lymphocytes/Immunology
  • Base Sequence
  • Cell Division
  • Cell Line
  • Chromosome Mapping
  • Chromosomes
  • Human
  • Pair 13/Genetics
  • Cloning
  • Molecular
  • Dna Primers/Genetics
  • Dendritic Cells/Immunology
  • Humans
  • Ligands
  • Lymphocyte Activation
  • Membrane Proteins/Genetics
  • Membrane Proteins/Physiology
  • Mice
  • Molecular Sequence Data
  • Receptors
  • Tumor Necrosis Factor/Genetics
  • Receptors
  • Tumor Necrosis Factor/Physiology
  • Sequence Homology
  • Amino Acid
  • T-Lymphocytes/Immunology
  • Tumor Necrosis Factor-Alpha/Genetics
  • Tumor Necrosis Factor-Alpha/Physiology
Disciplines
  • Biology
  • Design

Abstract

Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells. Human BAFF was mapped to chromosome 13q32-34. Membrane-bound BAFF was processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The expression of BAFF receptor appeared to be restricted to B cells. Both membrane-bound and soluble BAFF induced proliferation of anti-immunoglobulin M-stimulated peripheral blood B lymphocytes. Moreover, increased amounts of immunoglobulins were found in supernatants of germinal center-like B cells costimulated with BAFF. These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function.

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