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Determination of the antigenotoxic potencies of some luteolin derivatives by using a eukaryotic cell system, Saccharomyces cerevisiae

Authors
Journal
Food Chemistry
0308-8146
Publisher
Elsevier
Publication Date
Volume
141
Issue
1
Identifiers
DOI: 10.1016/j.foodchem.2013.02.089
Keywords
  • Yeast Del Assay
  • Saccharomyces Cerevisiae
  • Antimutagenicity
  • Luteolin Derivatives

Abstract

Abstract In this study, we aimed to examine the mutagenic and antimutagenic potencies of three luteolin derivatives (luteolin-7-O-glucoside, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide) by using a eukaryotic cell system, Saccharomyces cerevisiae (RS112). In the antimutagenicity assays, these luteolin derivatives showed antimutagenic effects in deletion and intrachromosomal recombination events against ethyl methanesulfonate and acridine mutagen agents. In deletion events, the highest inhibition rates for luteolin-7-O-glucoside, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide against ethyl methanesulfonate were 57.6%, 58.3% and 62.5%, respectively. Likewise, the highest inhibition rates for luteolin-7-O-glucoside, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide against acridin were 21.8%, 22.4% and 23.6%, respectively. Our findings showed that these luteolin derivatives have stronger antimutagenic properties against ethyl methanesulfonate compared to the acridine mutagen agent.

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