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3β-hydroxy-6α-methylpregn-4-en-20-one

Authors
Journal
Steroids
0039-128X
Publisher
Elsevier
Publication Date
Volume
2
Issue
1
Identifiers
DOI: 10.1016/s0039-128x(63)80037-9

Abstract

The title compound has been synthesized by an established route and also by a sequence using the Serini reaction. This compound has about twice the progestational potency of progesterone by injection and is anti-estrogenic. 20-Ethylenedioxy-6α-methylpregn-4-en-3-one and 20-ethylenedioxy-6α-methylpregn-4-3β-ol acetate possess both anti-estrogenic and anti-androgenic activity in the testosterone-stimulated castrated mouse. 3β-Hydroxy-6α-methylpregn-4-en-20-one acetate was anti-androgenic when inuncted on the testosterone-stimulated chick comb.

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