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Simple and rapid determination of the drug naproxen in pharmaceutical preparations by heavy atom-induced room temperature phosphorescence

Authors
Journal
Talanta
0039-9140
Publisher
Elsevier
Publication Date
Volume
50
Issue
2
Identifiers
DOI: 10.1016/s0039-9140(99)00126-5
Keywords
  • Heavy Atom Induced
  • Naproxen
  • Room Temperature Phosphorescence
Disciplines
  • Pharmacology

Abstract

Abstract A simple, selective and sensitive heavy atom-induced room temperature phosphorimetric method (HAI-RTP) is described for the determination of naproxen (NAP) in pharmaceutical preparations. The phosphorescence signals are a consequence of intermolecular protection when analytes are, exclusively, in presence of a heavy atom salt and sodium sulfite as an oxygen scavenger to minimize RTP quenching. These variables selection constitute the basis of a HAI-RTP method for the determination of naproxen (detection limit 17.6 ng ml −1; 1.71% relative standard deviation at 250 ng ml −1). The method has been applied satisfactorily to the analysis of pharmaceutical preparations.

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