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Casida Receives International Wolf Prize

Environmental Health Perspectives
Environmental Health Perspectives
Publication Date
  • Environews: Niehs News
  • Chemistry
  • Medicine


ae prediction process do not account for the multitude of differences between rodents and humans. In addition, Shelby pointed out that some computer predictions were not subjected to review by human experts at the end of the analyses, and called for "one more loop through the human mind" before results are offered as predictions. Two challenges presented at the w shop were how to deal with equ 4 results in rodent cancer bioassay 1 assessing their predictions and tion of how carcinogenic potency can predicted. Workshop participants noted that confirmation of their predictions depend on the rodent bioassay, which has some limitations. Because concordance between rat and mouse bioassays is only about 70%, this might represent an upper limit for extrapolating from rodent car- cinogens to human carcinogens. In consid- ering the limitations of the predictive process, Ashby said "Although we have had successes, there is a limit to how far such methods can be refined." At the end of the workshop, Bernard Schwetz, acting director of the Environ- mental Toxicology Program at NIEHS, indicated that a variety of prediction meth- ods were under consideration as aids for prioritizing chemicals for rodent carcino- genicity bioassays. A list of chemicals cur-E rently being tested in rodent bioassays was distributed, and participants were invited to use this list to further develop their pre- diction methods. Participants proposed that a similar workshop in about 3 years to 'Predicting Chemical Carcinogenesis in Rodents' Scientffic Program Committee (left to right) Joseph Wachsman, Stanley Stasiewicz, John Ashby, Raymond Tennant, Michael Shelby, Judson Spalding, and Douglas Bristol evaluate results of new predcai0sk a to review progress in the 4 p 4 diction methods. NTP The A~ logy and carC chmicals at ptevewmneeting.4:, ~ *ort involve%i sttditn wt4 mleand fi& h mice are given a range of doses of the chemical for 14 days, 13 weeks, and then 2 years. In each study extensive histopat'ho-logic diagnoses

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