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Interleukin-6 is pyrogenic but not somnogenic

Authors
Journal
Physiology & Behavior
0031-9384
Publisher
Elsevier
Publication Date
Volume
45
Issue
5
Identifiers
DOI: 10.1016/0031-9384(89)90239-4
Keywords
  • Sleep
  • Fever
  • Cytokine
  • Interleukin-1
  • Interleukin-6
  • Acute Phase Response
Disciplines
  • Biology

Abstract

Abstract Interleukin-6 (IL6) induces acute phase protein production and is hypothesized to mediate systemic and central effects of IL1. To determine whether IL6 possesses somnogenic properties, rabbits were injected intracerebroventricularly with IL6; sleep-wake activity was determined and brain temperatures recorded for 6 hr. IL6 induced fever in a dose-related manner with no effect on sleep-wake activity. IL6, therefore, is the first cytokine reported to elicit fever without promoting sleep. We conclude that the somnogenic action of IL1 is not mediated through IL6.

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