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Retroviral pseudotypes produced by rescue of a moloney murine leukemia virus vector by C-type, but not D-type, retroviruses

Authors
Journal
Virology
0042-6822
Publisher
Elsevier
Publication Date
Volume
186
Issue
2
Identifiers
DOI: 10.1016/0042-6822(92)90049-u

Abstract

Abstract Human HOS cells containing a Moloney murine leukemia virus (Mo-MLV) recombinant genome were infected by a panel of retroviruses. The C-type viruses simian sarcoma associated virus, feline leukemia virus subgroup B, and the feline endogenous virus RD114 were able to form pseudotypes with the Mo-MLV genome, which transferred a selectable marker gene to target cells; however, Human T cell leukemia virus-1 and the D-type viruses Mason-Pfizer monkey virus and simian retrovirus-1 failed to rescue the Mo-MLV vector. Further characterization of the RD114 pseudotype demonstrated that it retained the receptor specificity of RD114 and will therefore prove useful in receptor characterization.

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