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Anorectic effect of dehydroepiandrosterone combined with dexfenfluramine or thionisoxetine

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
419
Issue
1
Identifiers
DOI: 10.1016/s0014-2999(01)00958-x
Keywords
  • Dessert Test
  • 5-Ht (5-Hydroxytryptamine
  • Serotonin)
  • Norepinephrine
  • Isobologram
  • Additivity
  • Synergy

Abstract

Abstract Free feeding rats given supplementary 1 h access per day to a palatable dessert test meal were tested for the anorectic effect of dehydroepiandrosterone alone or in combination with either the serotonin releasing agent dexfenfluramine or the norepinephrine uptake inhibitor thionisoxetine (LY 368975). Isobolographic analysis showed that the effect of dehydroepiandrosterone combined with either dexfenfluramine or thionisoxetine was within the range predicted for additivity of action.

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