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FeCl3-catalyzed conjugate addition of secondary amines, imidazole and pyrazole to methyl 2-acetamidoacrylate. Preparation of β-dialkylamino-αalanine and β-(N-heteroaryi)-α-alanine derivatives

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
51
Issue
30
Identifiers
DOI: 10.1016/0040-4020(95)00446-f

Abstract

Abstract β-Dialkylamino-α-alanine and β-( N-heteroaryl)-α-alanine derivatives are obtained by conjugate addition of nitrogen based nuclcophiles (cyclic and acyclic secondary amines, imidazole and pirazole) to methyl 2-acetamidoacrylate, 1, under iron(III) chloride catalysis.

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